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Sigma-Aldrich Colistin Sulfate Ready Made Solution 1&
List Price $108.00 Your Price $108.00
Sigma-Aldrich Colistin Sulfate Ready Made Solution 1& - SIALGSK (Additional S&H or Hazmat Fees May Apply)
NETA PART: SIALGSK-SBR0012325ML
MFG.PART: SBR00123-25ML
UNSPSC: 51102800
Manufacturer: Sigma-Aldrich
Quality Level
200
form
ready-to-use solution
concentration
10 mg/mL (in H2O)
color
colorless to yellow
antibiotic activity spectrum
Gram-negative bacteria
mode of action
cell membrane | interferes
shipped in
dry ice
storage temp.
2-8°C
SMILES string
CCC(C)CCCC(=O)N[C@@H](CCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)CCN)CC(C)C)CC(C)C)CCN)CCN)[C@@H](C)O
InChI
1S/C53H100N16O13.H2O4S/c1-9-30(6)12-10-11-13-41(72)60-33(14-20-54)48(77)69-43(32(8)71)53(82)65-36(17-23-57)45(74)64-38-19-25-59-52(81)42(31(7)70)68-49(78)37(18-24-58)62-44(73)34(15-21-55)63-50(79)39(26-28(2)3)67-51(80)40(27-29(4)5)66-46(75)35(16-22-56)61-47(38)76;1-5(2,3)4/h28-40,42-43,70-71H,9-27,54-58H2,1-8H3,(H,59,81)(H,60,72)(H,61,76)(H,62,73)(H,63,79)(H,64,74)(H,65,82)(H,66,75)(H,67,80)(H,68,78)(H,69,77);(H2,1,2,3,4)/t30?,31-,32-,33+,34+,35+,36+,37+,38+,39+,40-,42+,43+;/m1./s1
General description
Colistin (Polymyxin E) is a polycationic peptide antimicrobial agent that inhibits gram negative bacteria.
Application
- Colistin has been used for multi drug resistant infections bacilli like: Enterobacterales, Pseudomonas aeruginosa, Acinetobacter baumannii.[9-13]
- To permeabilize to bacteria cell membrane to learn mannose-resistant haemagglutination and antibiotic resistance in A. baumannii strain.[14]
- For nephrotoxicity study in rat kidney.[15] and for MICs, time-kill kinetics, and postantibiotic effect (PAE) against Pseudomonas aeruginosa.[16]
- To induce cell toxicity in 24h on PC-12 cell line, causing decrease of cell viability ~by 75% with concentration of 125µg/mL colistin sulfate.[17]
- To show cell toxicity affect in dose (3-100µg/mL) dependent manner against HK-2 cells as part of a study to learn on the mechanism of colistin inducing nephrotoxicity.[18]
Biochem/physiol Actions
Mode of Action: Colistin mode of action is by forming electrostatic interaction with lipid A phosphate groups of lipopolysaccharide (LPS) of gram negative bacilli1 and disrupting physical integrity of the cell wall.2 Colistin shows indirect anti-endotoxin activity by binding to lipid A as it targets the endotoxin and neutralize the LPS component of the bacteria.[3-5]
Antimicrobial Spectrum: Colistin has microbial activity against Enterobacteriaceae family members like E. coli, Enterobacter spp., Klebsiella spp., Citrobacter spp., Salmonella spp., and Shigella spp. Colistin is also active against nonfermentive gram-negative bacteria, like Acinetobacter baumannii, Pseudomonas aeruginosa, and Stenotrophomonas maltophilia [6-8] and also against other gram negative species.[9]
Antimicrobial Spectrum: Colistin has microbial activity against Enterobacteriaceae family members like E. coli, Enterobacter spp., Klebsiella spp., Citrobacter spp., Salmonella spp., and Shigella spp. Colistin is also active against nonfermentive gram-negative bacteria, like Acinetobacter baumannii, Pseudomonas aeruginosa, and Stenotrophomonas maltophilia [6-8] and also against other gram negative species.[9]
Features and Benefits
High quality antibiotic suitable for mulitple research applications
Preparation Note
Colistin Ready Made Solution is provided as a solution of 10mg/mL in water and aseptically dispensed.Colistin concentration range for the uses or applications mentioned above is 0.25-125µg/mL.Colistin Ready Made Solution should be diluted respectively by 80-40,000.
| SKU | SIALGSK-SBR0012325ML |
|---|---|
| Supplier Part Number | SBR00123-25ML |
| UM | EA |
| UNSPSC | 51102800 |
| Manufacturer | Sigma-Aldrich |
| ProductLine | SIALGSK |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 9 |
| Energy Star | No |
| Green | No |
| Controlled | N |