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Sigma-Aldrich L-Anap Trifluoroacetate
List Price $629.00 Your Price $629.00
Sigma-Aldrich L-Anap Trifluoroacetate; 50 mg - SIALGSK (Additional S&H or Hazmat Fees May Apply)
NETA PART: SIALGSK-SML4210-50MG
MFG.PART: SML4210-50MG
UNSPSC: 12352209
Manufacturer: Sigma-Aldrich
Quality Level
100
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
SMILES string
OC([C@@H](N)CNC1=CC2=C(C=C1)C=C(C=C2)C(C)=O)=O
Biochem/physiol Actions
Fluorescent structural probe that enables real-time monitoring of ion channel dynamics through site-specific incorporation and environmental sensitivity.
L-ANAP (ANAP) is a bright fluorescent amino acid that can be site-specifically incorporated into proteins using amber stop codon suppression, making it ideal for studying ion channel dynamics in real-time. Anap features optimal spectral properties with λex ~ 360 nm and environment-dependent λem ~ 490 nm, Φ of 0.22–0.5, and an ϵ of 17.5 mm−1 cm−1 in water. Due to its environmental sensitivity and ability to serve as a FRET donor, ANAP enables simultaneous monitoring of protein conformational changes, ligand binding, protein-protein interactions, and temperature sensitivity while maintaining channel function. ANAP’s versatility is demonstrated through successful applications in various cell types (Xenopus oocytes, HEK-293, CHO, tSA-201 cells), where it can be combined with electrical recordings to provide direct correlation between structural states and channel function.
L-ANAP (ANAP) is a bright fluorescent amino acid that can be site-specifically incorporated into proteins using amber stop codon suppression, making it ideal for studying ion channel dynamics in real-time. Anap features optimal spectral properties with λex ~ 360 nm and environment-dependent λem ~ 490 nm, Φ of 0.22–0.5, and an ϵ of 17.5 mm−1 cm−1 in water. Due to its environmental sensitivity and ability to serve as a FRET donor, ANAP enables simultaneous monitoring of protein conformational changes, ligand binding, protein-protein interactions, and temperature sensitivity while maintaining channel function. ANAP’s versatility is demonstrated through successful applications in various cell types (Xenopus oocytes, HEK-293, CHO, tSA-201 cells), where it can be combined with electrical recordings to provide direct correlation between structural states and channel function.
Disclaimer
Hygroscopic Store with dessicant
| SKU | SIALGSK-SML4210-50MG |
|---|---|
| Supplier Part Number | SML4210-50MG |
| UM | EA |
| UNSPSC | 12352209 |
| Manufacturer | Sigma-Aldrich |
| ProductLine | SIALGSK |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 9 |
| CAS Number | 1313516-26-5 |
| Energy Star | No |
| Green | No |
| Controlled | N |