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Sigma-Aldrich Smcϩ Human Ctla4 Immunoassay Kit
List Price
$1,250.00
Your Price
$1,250.00
Sigma-Aldrich Smcϩ Human Ctla4 Immunoassay Kit - SIALGSK (Additional S&H or Hazmat Fees May Apply)
NETA PART:
SIALGSK-03-0220-00
MFG.PART:
03-0220-00
UNSPSC:
41116126
Manufacturer:
Sigma-Aldrich
description
Kit sufficient for 96 wells
Quality Level
200
quality
200
species reactivity
human
manufacturer/tradename
SMC®
assay range
linearity: 113%
(plasma)
linearity: 115%
(serum)
recovery range: 116%
(plasma)
recovery range: 127%
(serum)
sensitivity: 0.1-0.91pg/mL
(Refer to CoA for lot-specific LLOQ)
standard curve range: 0.03-2,000pg/mL
technique(s)
single molecule counting: suitable
input
sample type serum
sample type plasma (K2EDTA)
shipped in
wet ice
storage temp.
2-8°C
Related Categories
AAW™ Automated Assay Workstation
Immunoassay Platform Solutions
Lab Automation
SMC® High Sensitivity Immunoassay Kits
General description
Cytotoxic T-lymphocyte protein 4 (CTLA-4) is an immune checkpoint receptor that plays a crucial role in regulating immune responses. By downregulating T cell activity, CTLA-4 helps prevent excessive immune reactions that could lead to tissue damage and autoimmune disease. However, in the context of cancer, CTLA-4 can be exploited by tumors to evade immune detection and destruction. This has led to the development of CTLA-4 inhibitors, which are used in cancer immunotherapy to enhance the immune system′s ability to target and eliminate tumor cells. CTLA-4 is a critical component of the immune system, balancing the need for effective immune responses against the risk of autoimmunity.
Application
For ultrasensitive detection of CTLA-4 in human serum and plasma
Features and Benefits
Features:
- Robustness and Reproducibility: Lot-matched components ensure consistent assay performance across experiments, reducing variability and enhancing data reliability.
- Enhanced Detection Limits: Capable of detecting ultra-low analyte levels in the picogram and femtogram range, enabling the study of low-abundance biomarkers critical in early-stage research.
- Simplified Workflow Compatibility: Designed to align with standard assay workflows, including ELISA, minimizing the need for additional training or protocol adjustments.
- Certified Data Assurance: Each kit includes a Certificate of Analysis detailing validated assay characteristics, ensuring traceability and quality control for regulatory compliance.
- Wide Dynamic Range: Accurately quantifies analyte concentrations across a broad range, supporting both high and low abundance detection in complex samples.
- Automation Ready: Compatible with high-throughput systems, enabling seamless integration into automated workflows, reducing manual handling errors, and increasing efficiency.
- Understanding Immune Regulation: Ultrasensitive measurement of CTLA-4 allows researchers to explore immune modulation mechanisms, contributing to a deeper understanding of immune responses in various biological contexts.
- Modeling Disease Mechanisms: By measuring CTLA-4 levels, researchers can investigate its role in disease models, providing insights into the pathophysiology of conditions such as cancer and autoimmune diseases.
- Evaluating Therapeutic Strategies: In pre-clinical studies, monitoring CTLA-4 levels can help assess the effectiveness of novel immunotherapies or other treatments aimed at modulating immune responses.
- Biomarker Discovery: The ability to measure CTLA-4 sensitively may aid in identifying potential biomarkers for immune-related conditions, enhancing predictive models in research.
- Facilitating Drug Development: Understanding the dynamics of CTLA-4 in pre-clinical models can inform drug development processes, guiding the design of more effective therapies targeting immune checkpoints.
Legal Information
SMC is a registered trademark of Singulex
pictograms
GHS08,GHS07
signalword
Danger
hcodes
H302 + H312 + H332,H319,H360FD,H373,H412
pcodes
P273 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P308 + P313
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Irrit. 2 - Repr. 1B - STOT RE 2 Inhalation
target_organs
Respiratory Tract
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk_germany
WGK 3
| SKU | SIALGSK-03-0220-00 |
|---|---|
| Supplier Part Number | 03-0220-00 |
| UM | EA |
| UNSPSC | 41116126 |
| Manufacturer | Sigma-Aldrich |
| ProductLine | SIALGSK |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 9 |
| Hazardous | N |
| Energy Star | No |
| Green | No |
| Controlled | N |