We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn about our cookie policy.
Sigma-Aldrich Au-15330
List Price
$856.00
Your Price
$856.00
Sigma-Aldrich Au-15330; 25 mg - SIALGSK (Additional S&H or Hazmat Fees May Apply)
NETA PART:
SIALGSK-SML4159-25MG
MFG.PART:
SML4159-25MG
UNSPSC:
12350000
Manufacturer:
Sigma-Aldrich
Quality Level
100
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2mg/mL, clear
storage temp.
-10 to -25°C
SMILES string
NC1=C(C=C(C2=C(C=CC=C2)O)N=N1)N(CC3)CCN3CC(N[C@@H](C(C)(C)C)C(N4[C@@H](C[C@H](C4)O)C(N[C@H](C5=CC=C(C6=C(N=CS6)C)C=C5)C)=O)=O)=O
General description
AU-15330 is a highly-selective proteolysis-targeting chimera (PROTAC) degrader of both SWItch/SucroseNon-Fermentable (SWI/SNF) adenosinetriphosphatase (ATPase) subunits— SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily A member 2 & 4 SMARCA2 (BRM)and SMARCA4 (BRG1) SWI/SNF ATPases. It potently inhibits tumor growth in xenograft models of prostate cancer. AU-15330 comprises a bait moiety that binds the bromodomain in SMARCA2 and SMARCA4 and a ligand moiety for the von Hippel–Lindau (VHL) ubiquitin ligase. It synergized with the androgen receptor antagonist enzalutamide.
Biochem/physiol Actions
Highly-selective PROTAC degrader of both SWI/SNF ATPase subunits—SMARCA2 (BRM) and SMARCA4 (BRG1) SWI/SNF ATPases.
AU-15330 is a highly-selective PROTAC degrader of both SWI/SNF ATPase subunits—SMARCA2 (BRM) and SMARCA4 (BRG1) SWI/SNF ATPases. It potently inhibits tumor growth in xenograft models of prostate cancer. AU-15330 comprises a bait moiety that binds the bromodomain in SMARCA2 and SMARCA4 and a ligand moiety for the von Hippel–Lindau (VHL) ubiquitin ligase. It synergized with the androgen receptor antagonist enzalutamide.
AU-15330 is a highly-selective PROTAC degrader of both SWI/SNF ATPase subunits—SMARCA2 (BRM) and SMARCA4 (BRG1) SWI/SNF ATPases. It potently inhibits tumor growth in xenograft models of prostate cancer. AU-15330 comprises a bait moiety that binds the bromodomain in SMARCA2 and SMARCA4 and a ligand moiety for the von Hippel–Lindau (VHL) ubiquitin ligase. It synergized with the androgen receptor antagonist enzalutamide.
| SKU | SIALGSK-SML4159-25MG |
|---|---|
| Supplier Part Number | SML4159-25MG |
| UM | EA |
| UNSPSC | 12350000 |
| Manufacturer | Sigma-Aldrich |
| ProductLine | SIALGSK |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 9 |
| CAS Number | 2380274-50-8 |
| Energy Star | No |
| Green | No |
| Controlled | N |