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Sigma-Aldrich I-Bet787
List Price
$119.00
Your Price
$119.00
Sigma-Aldrich I-Bet787 - SIALGSK (Additional S&H or Hazmat Fees May Apply)
NETA PART:
SIALGSK-SML4205-5MG
MFG.PART:
SML4205-5MG
UNSPSC:
12352200
Manufacturer:
Sigma-Aldrich
Quality Level
100
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2mg/mL, clear
storage temp.
2-8°C
Biochem/physiol Actions
Orally active, potent and selective pan-BET family bromodomain (BrD) inhibitor. I-BET787 is an orally active, potent and selective pan-BET bromodomain (BrD) inhibitor (BRD2/3/4/T pIC50 =6.9/7.1/7.1/6.3/BrD1 5.7/6.2/5.9/5.1/BrD2) that demonstrates efficacy in an inflammation model in mice in vivo (5 & 15 mg/kg b.i.d. p.o. for 14 days)by suppressing KLH-TNP (100 μg/kg via i.p. 1h post first I-BET787 oral dosing)-induced T-cell activation.
| SKU | SIALGSK-SML4205-5MG |
|---|---|
| Supplier Part Number | SML4205-5MG |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Sigma-Aldrich |
| ProductLine | SIALGSK |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 9 |
| CAS Number | 2201082-98-4 |
| Energy Star | No |
| Green | No |
| Controlled | N |