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Sigma-Aldrich Org 34167
List Price $513.00 Your Price $513.00
Sigma-Aldrich Org 34167; 10 mg - SIALGSK (Additional S&H or Hazmat Fees May Apply)
NETA PART: SIALGSK-SML3939-10MG
MFG.PART: SML3939-10MG
UNSPSC: 12352100
Manufacturer: Sigma-Aldrich
Quality Level
100
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
DMSO: 2mg/mL, clear
storage temp.
2-8°C
SMILES string
C=CC[C@H](N)C(C=CC=C1)=C1C2=NOC3=CC=CC=C32.Cl
Biochem/physiol Actions
Brain penetrant, potent and selective modulator of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels that exhibit antidepressant activity.
Org 34167 is a brain penetrant, potent and selective modulator of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels that exhibit antidepressant activity in human and rat models. Apparently, Org 34167 inhibits HCN1 channel activity by modulating hyperpolarizing shift in activation voltage dependence and a slowing of activation kinetics.
Org 34167 is a brain penetrant, potent and selective modulator of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels that exhibit antidepressant activity in human and rat models. Apparently, Org 34167 inhibits HCN1 channel activity by modulating hyperpolarizing shift in activation voltage dependence and a slowing of activation kinetics.
Disclaimer
Hygroscopic
| SKU | SIALGSK-SML3939-10MG |
|---|---|
| Supplier Part Number | SML3939-10MG |
| UM | EA |
| UNSPSC | 12352100 |
| Manufacturer | Sigma-Aldrich |
| ProductLine | SIALGSK |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 9 |
| Energy Star | No |
| Green | No |
| Controlled | N |