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Sigma-Aldrich Chidamide
List Price
$399.00
Your Price
$399.00
Sigma-Aldrich Chidamide - SIALGSK (Additional S&H or Hazmat Fees May Apply)
NETA PART:
SIALGSK-SML4257-50MG
MFG.PART:
SML4257-50MG
UNSPSC:
51000000
Manufacturer:
Sigma-Aldrich
Quality Level
100
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
General description
An orally available histone deaceylases HDAC1/2/3/8/10/11 inhibitor with anti-cancer efficacy both in cultures and in vivo.
Chidamide (CS055, HBI-8000, Tucidinostat) is an orally available benzamide that inhibits against class I histone deaceylases HDAC1/2/3/8 (IC50 of 95/160/67/733 nM), class II2b HDAC10 (IC50 = 78 nM), and class IV HDAC11 (IC50 = 432 nM), but not class IIa HDAC4/5/7/9 or IIb HDAC10 (IC50 >30 μM). Chidamide effectively upregulates cellular acetylation levels of histone H3 and H4 (3 μM for 24 H in SKM-1 and HEL cultures) and exhibits anti-cancer efficacy both in cultures and in vivo.
Chidamide (CS055, HBI-8000, Tucidinostat) is an orally available benzamide that inhibits against class I histone deaceylases HDAC1/2/3/8 (IC50 of 95/160/67/733 nM), class II2b HDAC10 (IC50 = 78 nM), and class IV HDAC11 (IC50 = 432 nM), but not class IIa HDAC4/5/7/9 or IIb HDAC10 (IC50 >30 μM). Chidamide effectively upregulates cellular acetylation levels of histone H3 and H4 (3 μM for 24 H in SKM-1 and HEL cultures) and exhibits anti-cancer efficacy both in cultures and in vivo.
| SKU | SIALGSK-SML4257-50MG |
|---|---|
| Supplier Part Number | SML4257-50MG |
| UM | EA |
| UNSPSC | 51000000 |
| Manufacturer | Sigma-Aldrich |
| ProductLine | SIALGSK |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 9 |
| CAS Number | 1616493-44-7 |
| Energy Star | No |
| Green | No |
| Controlled | N |