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Sigma-Aldrich Ted-347
List Price
$642.00
Your Price
$642.00
Sigma-Aldrich Ted-347; 25 mg - SIALGSK (Additional S&H or Hazmat Fees May Apply)
NETA PART:
SIALGSK-SML4158-25MG
MFG.PART:
SML4158-25MG
UNSPSC:
12350000
Manufacturer:
Sigma-Aldrich
Quality Level
100
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2mg/mL, clear
storage temp.
-10 to -25°C
SMILES string
O=C(C1=CC=CC=C1NC2=CC(C(F)(F)F)=CC=C2)CCl
General description
TED-347is a potent and selective allosteric inhibitor of the transcriptional enhanced associate domain (TEAD)-yes-associated protein 1 (Yap1) protein-protein interaction (EC50 =5.9 µM) that inhibits TEAD transcriptional activity. It potentlyinhibits growth of spheroids of patient-derived GBM43 glioblastoma cell lines.TED-347 binds to the TEAD4 palmitate pocket where it forms covalent bond withCys-367.
Application
TED-347 is used to probe the how dysregulation ofYAP-TEAD signalling relates to glioblastoma proliferations
Biochem/physiol Actions
Potent and selective allosteric inhibitor of the TEAD-Yap1 protein-protein interaction that inhibits TEAD transcriptional activity.
TED-347 is a potent and selective allosteric inhibitor of the TEAD-Yap1 protein-protein interaction (EC50 = 5.9 µM) that inhibits TEAD transcriptional activity. TED-347 potently inhibits growth of spheroids of patient-derived GBM43 glioblastoma cell lines. TED-347 binds to the TEAD4 palmitate pocket where it forms covalent bond with Cys-367.
TED-347 is a potent and selective allosteric inhibitor of the TEAD-Yap1 protein-protein interaction (EC50 = 5.9 µM) that inhibits TEAD transcriptional activity. TED-347 potently inhibits growth of spheroids of patient-derived GBM43 glioblastoma cell lines. TED-347 binds to the TEAD4 palmitate pocket where it forms covalent bond with Cys-367.
| SKU | SIALGSK-SML4158-25MG |
|---|---|
| Supplier Part Number | SML4158-25MG |
| UM | EA |
| UNSPSC | 12350000 |
| Manufacturer | Sigma-Aldrich |
| ProductLine | SIALGSK |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 9 |
| CAS Number | 2378626-29-8 |
| Energy Star | No |
| Green | No |
| Controlled | N |