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Sigma-Aldrich Atm Kinase Inhibitor 1Pc X 10Mg
List Price $335.00 Your Price $335.00
Sigma-Aldrich Atm Kinase Inhibitor 1Pc X 10Mg - SIALGSK (Additional S&H or Hazmat Fees May Apply)
NETA PART: SIALGSK-118500-10MG
MFG.PART: 118500-10MG
UNSPSC: 12352200
Manufacturer: Sigma-Aldrich
Quality Level
100
SMILES string
O=C1C=C(OC(=C1)c2cccc3Sc4ccccc4Sc23)N5CCOCC5
InChI
1S/C21H17NO3S2/c23-14-12-16(25-20(13-14)22-8-10-24-11-9-22)15-4-3-7-19-21(15)27-18-6-2-1-5-17(18)26-19/h1-7,12-13H,8-11H2
InChI key
XRKYMMUGXMWDAO-UHFFFAOYSA-N
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Biochem/physiol Actions
KU-55933 is a very potent, specific inhibitor of Ataxia telangiectasia (A-T) mutated (ATM) kinase (IC50 = 13 nM). KU-22933 treatment sensitizes cancer cells to ionizing radiation and cytotoxic drugs. The compound KU-22933 blocks ATM-mediated phosphorylyation of p53, gH2AX, NBS1, and SMC1.
KU-55933 is a very potent, specific inhibitor of Ataxia telangiectasia (A-T) mutated (ATM) kinase.
| SKU | SIALGSK-118500-10MG |
|---|---|
| Supplier Part Number | 118500-10MG |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Sigma-Aldrich |
| ProductLine | SIALGSK |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 9 |
| CAS Number | 587871-26-9 |
| Energy Star | No |
| Green | No |
| Controlled | N |