Revvity HTRF Human & Mouse Phospho-HDAC4 (Ser246) Detection Kit, 10,000 Assay Points

Histone deacetylases (HDACs) regulate chromatin remodeling and subsequent gene transcription by controlling the status of histone acetylation. Histone deacetylation induces a condensed chromatin conformation, contributing to the repression of gene transcription, which is involved in diverse physiological processes.

Importantly, HDACs are dysregulated in a number of brain disorders. This is implicated in the pathogenesis of these diseases, autism, Alzheimers disease, and depressive disorders. It suggests that HDACs might be potential targets for the treatment of brain disorders.

Among class II HDACs, HDAC4 is a specific target for the treatment of ischemic stroke. It plays a key role in the pathogenesis of ischemic stroke, and also in post-stroke recovery by affecting neuronal death, angiogenesis, and neurogenesis.

Epigenetic pathways define biologically relevant subsets of human cancers. EZH2 activation and HDAC4 activation correlate with growth factor signaling and inflammation, respectively, and represent two distinct states for cancer cells. This understanding may enable us to identify targetable drivers in breast cancer and mesenchymal glioblastoma.