Revvity HTRF Dasatinib-Red, 1 nmol

This compound is derived from Dasatinib, which is a well known inhibitor of the BCR-ABL and SRC families of Kinases. Dasatinib, which is an ATP-competitive Kinase inhibitor, is used as a drug to treat chronic myelogenous leukemia and acute lymphoblastic leukemia. It has been shown to bind with an affinity of <100 nM to about 16% of the Kinases and mainly to RTK. It is therefore useful to address multiple Kinases in the HTRF Kinase Binding assay platform. The ‘d2’ fluorescent dye used absorbs with its maximum near 650 nm and fluoresces near 670 nm. It is used as an acceptor molecule in HTRF assays.

Dasatinib-Red is supplied as a 25 µM solution in DMSO.