Revvity HTRF Mouse Phospho-STING (Ser365) Detection Kit, 500 Assay Points

This HTRF cell-based assay conveniently and accurately quantifies mouse phosphorylated STING at Ser365. Following pathogen infection and binding of dsDNA to the cytoplasmic sensor cGAS, STING protein is phosphorylated by TBK1. This enables its binding to IRF3, which induces IFNs type 1 production and other immune responses. The STING pathway is then switched off by STING degradation involving autophagy.