Revvity HTRF Human Total HPK1 Detection Kit, 500 Assay Points

Hematopoietic progenitor kinase 1 (HPK1) is a serine/threonine kinase primarily involved in the regulation of immune cell signaling. It plays a crucial role in T-cell receptor (TCR) signaling by modulating downstream pathways that influence T-cell activation, proliferation, and differentiation. HPK1 negatively regulates TCR signaling by phosphorylating adaptor proteins such as SLP-76, which dampens T-cell responses. Additionally, HPK1 is involved in B-cell receptor (BCR) signaling, impacting B-cell activation and function. It also contributes to the innate immune response by modulating pathways in myeloid cells, such as dendritic cells and macrophages, affecting cytokine production and cell migration. Beyond immune cells, HPK1 has been implicated in the regulation of apoptosis and cell cycle progression, influencing hematopoietic cell homeostasis. Due to its regulatory roles, HPK1 is a potential therapeutic target for immune-related disorders and cancers.