Revvity HTRF Human Total CDK12 Detection Kit, 500 Assay Points

The Total CDK12 cellular assay monitors CDK12 protein levels.

CDK12 is a transcription-associated CDK. It complexes with cyclin K to regulate gene transcription elongation via the phosphorylation of RNA polymerase II (RNAP II), and also regulates translation. Moreover, CDK12 plays a role in RNA splicing, cell cycle progression, cell proliferation, DNA damage response (DDR), and the maintenance of genomic stability. Since the mutation or amplification of CDK12 is closely related with tumorigenesis, CDK12 has become an attractive therapeutic target for cancer treatments.