Revvity HTRF Human Phospho-RIPK1 (Ser166) Detection Kit, 500 Assay Points

This HTRF cell-based assay conveniently and accurately detects phosphorylated RIPK1 66. RIPK1 (Receptor-Interacting serine/threonine-Protein Kinase 1, also called RIP1 or RIP) is a iator of apoptotic and necrotic cell death, as well as of inflammatory pathways eam of TNFR1 and other receptors. utophosphorylation at Serine 166 is considered to be a biomarker of the initiation of RIPK3/MLKL-dependent necroptosis. roptosis ogrammed necrotic cell death pathway, also called "inflammatory cell death", s closely associated with pathologies including inflammatory and neurodegenerative diseases, as well as cancer. as therefore become an important drug target in the pharmaceutical industry. Therapeutic strategies consist in developing specific small-molecule kinase inhibitors, such as the well-known Necrostatin-1 and Necrostatin-1s.