Revvity HTRF Human Phospho-Cyclin B1 (Ser126) Detection Kit, 500 Assay Points

This HTRF cell-based assay provides a convenient and accurate way to detect phosphorylated Cyclin B1 at Ser126.

Cyclin B family members (including Cyclin B1 and Cyclin B2) are important regulators of cell cycle progression. They are integral mediators of the growth factor-dependent transition from G2 to Mitosis phases, playing the role of the regulatory subunit of CDK1.

Cyclin B1 is upregulated in the presence of extracellular mitogenic stimuli and is subsequently rapidly downregulated by proteasomal degradation following its phosphorylation on Ser126.

Cyclin B1 is often overexpressed in many cancers. Such abnormal overexpression of Cyclin B1 results in dysregulated CDK1 activity and can lead to tumorigenesis.