Revvity HTRF Human & Mouse Phospho-TDP-43 (Ser409) Detection Kit, 500 Assay Points

TAR DNA binding protein 43 (TDP-43) is a nucleic acid binding protein involved in RNA-related metabolism. Aggregated TDP-43 has been identified as a hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar dementia (FTLD), and more widely in several neurodegenerative diseases: TDP-43 proteinopathies. In pathological conditions (mutation or dysregulation), TDP-43 forms insoluble inclusion bodies in the cytoplasm of neurons in the brain and spinal cord. The TDP-43 Phospho-Ser409/410 assay detects human TDP-43 phosphorylated in cell lysates.