Revvity HTRF Human MDA5 Aggregation Detection Kit, 500 Assay Points

MDA-5 is an RIG-I-like receptor that acts as a cytoplasmic sensor of double stranded RNA, and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines.

It is understood to form aggregates along RNA strands when performing its nucleic acid sensing functions.

It may also play an important role in enhancing natural killer cell function, and may be involved in growth inhibition and apoptosis in several tumor cell lines.