Revvity IVISense Osteo 680 Fluorescent Probe (OsteoSense)

IVISense Osteo NIR fluorescent bisphosphonate imaging probes are designed to bind with high affinity to hydroxyapatite (HA) both in vivo and in vitro. Since HA is known to bind pyrophosphonates and phosphonates as well as synthetic bisphosphonates with high affinity, IVISense Osteo agents offer a safe and easy way to assess the subtle bone mineral changes that occur in bone growth, bone loss, and in diseases that damage bone, using subtherapeutic doses for imaging.

IVISense Osteo 680 is excited by 668 ± 10 mn excitation light and emits at 687 ± 10 mn. Including IVISense Isteo 680 in careful experimental design allows for multiplexing with other channels and/or imaging times, and SO can be paired with other probes to achieve maximum efficiency and flexibility in imaging.