Revvity HTRF Mouse CCL2 (MCP1) Detection Kit, 100,000 Assay Points

Also called MCP-1 (monocyte chemoattractant protein 1), CCL2 is a chemokine mainly secreted by monocytes, macrophages, and dendritic cells to attract monocytes, basophils, and T cells. CCL2 is involved in pathologies like psoriasis or arosclerosis. In brain, CCL2 is released by neurons, astrocytes, and microglia, and is part of neuro-inflammatory response observed in ischemia or Alzheimers disease. CCL2 is also secreted by adipocytes and can interfere with insulin signaling, thus suggesting a role in inflammation linked to diabetes.

Assessment of serum samples often requires enhanced sensitivity. In some cases, AlphaLISA assays may have sufficient sensitivity to enable detection of low levels of analytes in serum or plasma. When assaying, always follow recommended protocol and avoid highly haemolyzed samples.