We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn about our cookie policy.
Revvity HTRF Human Total mLKL Detection Kit, 50,000 Assay Points
List Price $52,530.00 Your Price $52,530.00
Revvity HTRF Human Total MLKL Detection Kit, 50,000 Assay Points - REV
NETA PART: REV-64MLKLTPEY
MFG.PART: 64MLKLTPEY
UNSPSC: 41122102
Manufacturer: Revvity
The Total-MLKL cellular assay monitors total MLKL, and can be used as a normalization assay with the Phospho-MLKL (Ser358) kit. This kit is compatible with the buffers from the phospho-MLKL kit, SO the same lysate can be used for analyses of both the phosphorylated and the total protein populations.
MLKL (Mixed lineage kinase domain-like protein) is a key mediator of apoptotic and necrotic cell death, as well as of inflammatory pathways downstream from TNFR1 and other receptors. MLKL is phosphorylated at Serine 358 by RIPK3, and is considered to be a biomarker of the initiation of RIPK1/RIPK3-dependent necroptosis.
Necroptosis is a programmed necrotic cell death pathway, also called "inflammatory cell death", which is closely associated with pathologies including inflammatory and neurodegenerative diseases, as well as cancer. MLKL has therefore become an important drug target for the pharmaceutical industry. Therapeutic strategies consist in developing specific small-molecule kinase inhibitors, such as the well-known Necrostatin-1 and Necrostatin-1s.
| SKU | REV-64MLKLTPEY |
|---|---|
| Supplier Part Number | 64MLKLTPEY |
| UM | EA |
| UNSPSC | 41122102 |
| Manufacturer | Revvity |
| CountryOfOrigin | France |
| ProductLine | REV |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| Energy Star | No |
| Green | No |
| Controlled | N |