Revvity HTRF Human Total GSPT1 Detection Kit, 50,000 Assay Points

The GSPT1 (G1 to S phase transition 1) protein, primarily known for its role in protein synthesis termination, has emerged as a hot target in drug discovery This is especially the case in Targeted Protein Degradation, as elevated levels of GSPT1 have been observed in certain cancers, including breast, lung, and ovarian cancers, as well as Acute Myeloid Lymphoma. Furthermore, GSPT1 may contribute to chemotherapy resistance in cancer cells. Its overexpression can lead to decreased sensitivity to anticancer drugs, making it a potential therapeutic target to overcome resistance.