Revvity HTRF Human Fibronectin EDA Detection Kit, 100,000 Assay Points

Fibronectin is a large glycoprotein of the extracellular matrix whose functions are connected to cell adhesion, growth, migration, and differentiation. Fibronectin level regulation is strongly related to inflammation and fibrotic disorders, as well as to the matrix re-organization that occurs in the environment of some cancers. Tumor containment, migration, and expansion are critically dependent on a tumors surrounding matrix and on key adhesive and/or fibrous proteins such as fibroncetin.

The EDA domain of fibronectin is an alternatively spliced version of fibronectin that is almost entirely absent from healthy tissues, and mostly expressed in active fibroblasts at injury or inflammation sites. Because of this special feature, EDA-fibronectin is a marker that is specific to fibroblast-induced fibrotic disorders, as well as being a readout of pro-fibrotic activity in a tumor matrix environment.