Revvity HTRF Human & Mouse Total RET Detection Kit, 50,000 Assay Points

The Total-RET cellular assay monitors total RET (short and long isoforms), and can be used as a normalization assay with the Phospho-RET (pan) kit. This kit is compatible with the buffers from the Phospho-RET kit, SO the same lysate can be used for analyses of both the phosphorylated and the total protein populations.

The proto-oncogene RET (Rearranged during Transfection), also known as c-Ret, is a receptor tyrosine kinase primarily expressed as two isoforms of 1072 & 1114 amino acids. RET activation by Glial cell line-derived neurotrophic Family Ligands (GFL) leads to its dimerization and autophosphorylation on intracellular Tyrosine residues. RET is required for the development of the nervous system and several other tissues. RET alterations have been detected in numerous human cancers. The development of highly selective and potent RET kinase inhibitors is therefore of great interest to treat RET-altered cancers. Recently, RET has also been linked to neurodegeneration.