Revvity HTRF Human & Mouse Total IRS2 Detection Kit, 50,000 Assay Points

Insulin receptor substrates (IRS) 1 and 2 are the primary substrates of Insulin/IGF1 receptors, and mediate cell growth/survival and metabolic homeostasis. While IRS1 is primarily found in adipose tissue, IRS2 is the predominant form in pancreatic-beta cells and the central nervous system (CNS). Decreased IRS2 levels are associated with diabetes and neurodegeneration, whereas highly overexpressed levels of IRS2 drive tumor motility and invasion. This cell-based assay measures the modulation of IRS2 protein levels.