Revvity Ethylcarboxamidoadenosine

5-N-Ethylcarboxamidoadenosine acts as an agonist at adenosine receptors, and is a vasodilator. Adenosine receptors are a group of GPCRs that play a role in blood flow.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (B_max), dissociation constants (K_d), association and dissociation rates (k_on and k_off), and inhibitor constants (K_i) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET811:

1. g S Firestein, D A Bullough, M D Erion, R Jimenez, M Ramirez-Weinhouse, J Barankiewicz, C W Smith, H E Gruber, K M Mullane. Inhibition of neutrophil adhesion by adenosine and an adenosine kinase inhibitor. The role of selectins. The Journal of Immunology January 1, 1995, 154 (1) 326-334.