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Cayman Cinnamyl-3,4-dihydroxy-α-Cyanocinnamate
List Price $74.00 Your Price $74.00
Cayman Cinnamyl-3,4-dihydroxy-α-Cyanocinnamate - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-10858-10
MFG.PART: 10858-10
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Cinnamyl-3,4-dihydroxy-α-cyanocinnamate (CDC) is an inhibitor of 5-lipoxygenase (5-LO; IC50 = 15 nM).1 It is selective for 5-LO over 12-LO and 15-LO (IC50s = 500 and 300 nM, respectively). CDC inhibits 5-LO product formation induced by the calcium ionophore A23187 (Item No. 11016) in isolated human polymorphonuclear leukocytes (PMNs), monocytes, and whole blood (IC50s = 0.5, 0.45, and 1.5 µM, respectively). In vivo, CDC (3.5 mg/kg) increases survival in a mouse model of lethal shock induced by platelet-activating factor (PAF). It also reduces pleural levels of leukotriene B4 (LTB4; Item No. 20110) in a rat model of carrageenan-induced pleurisy.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(2E)-2-cyano-
CAS Number
132465-11-3
Synonyms
- CDC
Molecular Formula
C19H15NO4
Formula Weight
321.3
Purity
≥97%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 20 mg/mL
- DMSO: 20 mg/mL
- DMSO:PBS (pH 7.2) (1:10): 0.1 mg/mL
- Ethanol: 0.25 mg/mL
λmax
251, 376 nm
SMILES
O=C(/C(C#N)=C/C1=CC=C(O)C(O)=C1)OC/C=C/C2=CC=CC=C2
InChi Code
InChI=1S/C19H15NO4/c20-13-16(11-15-8-9-17(21)18(22)12-15)19(23)24-10-4-7-14-5-2-1-3-6-14/h1-9,11-12,21-22H,10H2/b7-4+,16-11+
InChi Key
XGHYFEJMJXGPGN-UYHGDYIZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-10858-10 |
|---|---|
| Supplier Part Number | 10858-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | Y |
| CAS Number | 132465-11-3 |
| Energy Star | No |
| Green | No |
| Controlled | N |