Cayman Ethyl p-methoxycinnamate

Ethyl p-methoxycinnamate (EPMC) is a cinnamic acid ester that has been found in K. galanga and has diverse biological activities.^1,2,3 It is active against T. rubrum, A. niger, S. cerevisiae, and E. floccosum when used at concentrations less than 10 μg/ml.¹ EPMC inhibits COX-1 and COX-2 in vitro (IC₅₀s = 1.12 and 0.83 μM, respectively).² It inhibits microvessel sprouting in isolated rat aortic rings (IC₅₀ = 91.9 µg/ml).⁴ In vivo, EPMC (60 mg/kg) reduces IL-1 and TNF-α production and inhibits granuloma formation in a rat model of cotton pellet-induced granuloma formation. It also increases the latency to tail withdrawal in a hot plate test in rats when administered at doses ranging from 200 to 800 mg/kg.

WARNING This product is not for human or veterinary use.