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Cayman Ripasudil (hydrochloride hydrate)
List Price $263.00 Your Price $263.00
Cayman Ripasudil (hydrochloride hydrate) - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-19920-10
MFG.PART: 19920-10
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Ripasudil is an inhibitor of Rho-associated kinase 1 (ROCK1) and ROCK2 (IC50s = 51 and 19 nM, respectively).1 It is selective for ROCK1 and ROCK2 over protein kinase A catalytic subunit α (PKACα) and PKC (IC50s = 2,100 and >10,000 nM, respectively). Ripasudil (0.4%) reduces intraocular pressure in cynomolgus monkey to a greater extent than the prostaglandin FP receptor agonist latanoprost (Item No. 16812). It increases the outflow facility of the aqueous humor in rabbit eyes when administered in a 0.4% solution. Ripasudil (0.4%) decreases intraocular pressure, retinal ganglion cell death, and thinning of inner retinal layers, as well as improves retinal function, in an excitatory amino acid transporter 1 (EAAT1) knockout mouse model of normal tension glaucoma.2 Formulations containing ripasudil have been used in the treatment of glaucoma and ocular hypertension.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
4-fluoro-5-
CAS Number
887375-67-9
Synonyms
- K-115
Molecular Formula
C15H18FN3O2S • HCl [2H2O]
Formula Weight
395.9
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: Slightly soluble
- DMSO: 30 mg/mL
- PBS (pH 7.2): 0.5 mg/mL
λmax
211, 278, 324 nm
SMILES
FC1=C2C(C=CC=C2S(N3CCCNC[C@@H]3C)(=O)=O)=CN=C1.Cl.O.O
InChi Code
InChI=1S/C15H18FN3O2S.ClH.2H2O/c1-11-8-17-6-3-7-19(11)22(20,21)14-5-2-4-12-9-18-10-13(16)15(12)14;;;/h2,4-5,9-11,17H,3,6-8H2,1H3;1H;2*1H2/t11-;;;/m0.../s1
InChi Key
CMDJNMACGABCKQ-XVSRHIFFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-19920-10 |
|---|---|
| Supplier Part Number | 19920-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 887375-67-9 |
| Energy Star | No |
| Green | No |
| Controlled | N |