Cayman NADPH Cytochrome P450 Reductase (human, recombinant)

NADPH cytochrome P450 reductase (POR) is a flavoprotein and key electron donor to cytochrome P450s (CYPs).^1,2 It is composed of an N-terminal membrane anchor domain and FMN-binding domain, which is linked to a C-terminal FAD-binding domain and NADPH-binding domain and localized to the cytosolic side of the endoplasmic reticulum.^3,1,4 POR transfers electrons from NADPH through FAD and FMN coenzymes into the iron of the prosthetic heme group of CYPs.^3,1 Cortical levels of POR are increased in the APPswe/PSEN1dE9 transgenic mouse model of Alzheimer’s disease.⁵ Deficiency in POR is associated with ambiguous genitalia and the disruption of steroid metabolism in patients with Antley-Bixler syndrome.⁶ Cayman’s NADPH Cytochrome P450 Reductase (human, recombinant) can be used for enzyme activity assays.

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