Cayman Myelin Basic Protein Peptide (mouse, bovine) (trifluoroacetate salt)

ASP7663 is a transient receptor potential ankyrin 1 (TRPA1) agonist. It induces calcium influx in HEK293 cells expressing human, rat, or mouse TRPA1 (EC₅₀s = 0.51, 0.54, and 0.5 µM, respectively) and stimulates serotonin (5-HT) release from QGP-1 enterochromaffin cells that endogenously express TRPA1 (EC₅₀ = 72.5 µM). It reduces colonic transit time in mouse models of constipation induced by clonidine (Item No. ) or loperamide when administered orally at a dose of 1 mg/kg, an effect that can be blocked by vagotomy or the TRPA1 antagonist HC-030031 (Item No. ). ASP7663 (0.3 mg/kg, p.o.) reduces the number of abdominal contractions induced by colorectal distension in mice.

WARNING This product is not for human or veterinary use.