Cayman Creatine (hydrate)

Chemokine (C-C motif) ligand 5 (CCL5), also known as RANTES, is a pro-inflammatory chemokine and member of the CC subfamily of chemokines. It is composed of an unstructured N-terminal region, a flexible loop, a 3₁₀-helix, three strands of an antiparallel β-sheet, and a single C-terminal α helix. It is expressed in T cells, platelets, macrophages, tubular epithelial cells, synovial fibroblasts, and endothelial cells, as well as some tumor cells. It functions as a monomer or various oligomers and interacts with the G protein-coupled receptors (GPCRs) chemokine (C-C motif) receptor 1 (CCR1), CCR3, CCR4, CCR5, and GPR75 to activate cell signaling in an oligomerization state-dependent manner. It also interacts with the non-signaling receptors ACKR1, ACKR2, and CCRL2. CCL5 functions as a chemoattractant of immune cells that predominantly express CCR5, such as activated T cells and monocytes, as well as those expressing CCR1 and CCR3, including macrophages and eosinophils, respectively. Production of CCL5 is induced in response to viral infections, including HIV, rhinoviruses, respiratory syncytial virus (RSV), coronaviruses, and influenza. CCL5 expression positively correlates with disease progression in patients with breast cancer. Caymans CCL5/RANTES (human, recombinant) protein consists of 69 amino acids and has a calculated molecular weight of 8 kDa.

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