Cayman CYN 154806 (trifluoroacetate salt)

Theobromine-d₆ is intended for use as an internal standard for the quantification of theobromine (Item No. ) by GC- or LC-MS. Theobromine is a methylxanthine alkaloid and derivative of caffeine (Item No. ) that has been found in cocoa beans and has diverse biological activities.^,, It is an adenosine A₁ receptor antagonist (IC₅₀s = 200-280 μM in radioligand binding assays using rat brain membranes). Theobromine (150 μg/ml) increases AMPK phosphorylation and inhibits adipocyte differentiation, ERK and JNK phosphorylation, and IL-6 and TNF-α production in 3T3-L1 preadipocytes cultured in differentiation medium. It inhibits decreases in renal cortex SIRT1 activity and increases in NADPH oxidase-dependent reactive oxygen species (ROS) production, as well as reduces kidney hypertrophy and albuminuria in a spontaneously hypertensive rat model of streptozotocin-induced diabetes when administered at a dose of 5 mg/kg per day. Theobromine is toxic to dogs with an LD₅₀ value of 250 to 500 mg/kg.

WARNING This product is not for human or veterinary use.