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Cayman 2-Deoxy-5-fluorocytidine
List Price
$85.00
Your Price
$85.00
Cayman 2-Deoxy-5-fluorocytidine - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-37477-250
MFG.PART:
37477-250
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
2-Deoxy-5-fluorocytidine is an antimetabolite, an inhibitor of DNA methylation and deoxycytidine kinase, and a prodrug form of the FdUMP prodrug 5-fluorouracil (Item No. 14416).1,2,3,4 Incorporation of 2-deoxy-5-fluorocytidine into a synthetic DNA polymer inhibits methylation of DNA in a cell-free assay, and 2-deoxy-5-fluorocytidine-containing oligonucleotides form a covalent complex with DNA methyltransferase 3a (Dnmt3a).1,2 2-Deoxy-5-fluorocytidine inhibits deoxycytidine kinase (dCK; IC50 = 120 nM).3 It reduces the cytopathic effects of the influenza H5N1 strain Vietnam/1203/2004 in MDCK cells (IC50 = 0.19 µM).5 2-Deoxy-5-fluorocytidine (12 mg/kg) in combination with the cytidine deaminase inhibitor tetrahydrouridine (Item No. 16402) inhibits tumor growth in an ascitic mammary adenocarcinoma 755 murine model.4 It induces embryonic lethality and skeletal malformations in a dose-dependent manner when administered to pregnant mice.6
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
2-deoxy-5-
CAS Number
10356-76-0
Synonyms
- 2-DFCR
- 5-Fluoro-2′-deoxycytidine
- NSC 48006
- Ro 5-1090
Molecular Formula
C9H12FN3O4
Formula Weight
245.2
Purity
≥98%
Formulation(Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
- DMF: 20 mg/mL
- DMSO: 20 mg/mL
- Ethanol: 5 mg/mL
- PBS (pH 7.2): 5 mg/mL
SMILES
OC[C@@H]1[C@@H](O)C[C@@](N2C=C(F)C(N)=NC2=O)([H])O1
InChi Code
InChI=1S/C9H12FN3O4/c10-4-2-13(9(16)12-8(4)11)7-1-5(15)6(3-14)17-7/h2,5-7,14-15H,1,3H2,(H2,11,12,16)/t5-,6+,7+/m0/s1
InChi Key
IDYKCXHJJGMAEV-RRKCRQDMSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-37477-250 |
|---|---|
| Supplier Part Number | 37477-250 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 10356-76-0 |
| Energy Star | No |
| Green | No |
| Controlled | N |