Cayman 2-Deoxy-5-fluorocytidine

2-Deoxy-5-fluorocytidine is an antimetabolite, an inhibitor of DNA methylation and deoxycytidine kinase, and a prodrug form of the FdUMP prodrug 5-fluorouracil (Item No. 14416).^1,2,3,4 Incorporation of 2-deoxy-5-fluorocytidine into a synthetic DNA polymer inhibits methylation of DNA in a cell-free assay, and 2-deoxy-5-fluorocytidine-containing oligonucleotides form a covalent complex with DNA methyltransferase 3a (Dnmt3a).^1,2 2-Deoxy-5-fluorocytidine inhibits deoxycytidine kinase (dCK; IC₅₀ = 120 nM).³ It reduces the cytopathic effects of the influenza H5N1 strain Vietnam/1203/2004 in MDCK cells (IC₅₀ = 0.19 µM).⁵ 2-Deoxy-5-fluorocytidine (12 mg/kg) in combination with the cytidine deaminase inhibitor tetrahydrouridine (Item No. 16402) inhibits tumor growth in an ascitic mammary adenocarcinoma 755 murine model.⁴ It induces embryonic lethality and skeletal malformations in a dose-dependent manner when administered to pregnant mice.⁶

WARNING This product is not for human or veterinary use.