Cayman SCDase (Shewanella alga, recombinant)

Simvastatin-d₆ is intended for use as an internal standard for the quantification of simvastatin (Item Nos. | ) by GC- or LC-MS. Simvastatin is a competitive inhibitor of HMG-CoA reductase (K_i = 0.12 nM). Simvastatin reduces plasma cholesterol levels in rats and dogs when administered at doses of 1.2 and 8 mg/kg, respectively. Simvastatin suppresses TNF-induced NF-κB activation (IC₅₀ = ~13 µM) and potentiates apoptosis in human myeloid leukemia cells. It also inhibits glutathione peroxidase 4 (GPX4) activity, increases malondialdehyde (MDA) levels, and induces ferroptosis in MDA-MB-231 and MCF-7 breast cancer cells. Formulations containing simvastatin have been used in the treatment of dyslipidemias.

WARNING This product is not for human or veterinary use.