Cayman AA-T3A-C12

The biological effects of prostaglandin E₂ (PGE₂) are mediated through interaction with four distinct membrane-bound G-protein coupled EP receptors: EP₁, EP₂, EP₃, and EP₄.^, Binding of PGE₂ to the EP₂ receptor results in an increase in adenylate cyclase activity with a subsequent increase in cAMP.^, Pharmacologicially, EP₂ receptors mediate relaxation of smooth muscle and are distinguished from EP₄ receptors by their sensitivity to the EP₂ receptor selective agonist butaprost.^,, The human EP₂ receptor is comprised of 358 amino acids with a molecular mass of approximately 40,000. EP₂ is detected on immunoblot at 65 or 52 kDa depending on the degree of post-translational modifications of that receptor. mRNA for the EP₂ receptor is expressed in a variety of tissues including lung, placenta, spleen, intestine, kidney, and sensory neuron.^,,

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