Cayman C12-SPM

Cytosolic PGE synthase (cPGES) is a glutathione-dependent enzyme with a predicted size of 18.6 kDa (23 kDa on SDS-PAGE). The enzyme is expressed in a wide variety of tissues and cells, the levels of which are unaffected by treatment with IL-1β and TNFα. However, enzyme expression increases approximately 3-fold in rat brain following LPS treatment. Microsomal PGE synthase (mPGES) is a 16 kDa protein expressed in a variety of tissues. In contrast to cPGES, mPGES protein expression is increases in A549 cells following treatment with IL-1β. The two enzymes show <10% homology at the amino acid level.

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