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Cayman Ferritin PROTAC DeFer-2
List Price $85.00 Your Price $85.00
Cayman Ferritin PROTAC DeFer-2 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-38931-1
MFG.PART: 38931-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Ferritin PROTAC DeFer-2 is a proteolysis-targeting chimera (PROTAC) containing oleic acid (Item Nos. 90260 | 24659), which binds to ferritin dimers, conjugated to von Hippel-Lindau ligand (VHL ligand 1; Item No. 21591), which binds to VHL E3 ligase, via an alkyl linker.1 It induces ferritin degradation in B16/F10 murine melanoma cells when used at a concentration of 0.5 µM, an effect not induced by a negative control with an inverted VHL ligand 1 stereocenter, indicating that the E3 ligase activity of VHL ligand 1 is required for this effect. Ferritin PROTAC DeFer-2 (5 µM) increases intracellular levels of free iron and induces pyroptosis in B16/F10 cells. Ferritin PROTAC De-Fer-2 (10 mg/kg) encapsulated in albumin nanoparticles reduces tumor growth and increases survival in a B16/F10 murine melanoma model.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(2S,4R)-1-((S)-
Synonyms
- Ferritin Proteolysis-targeting Chimera DeFer2
Molecular Formula
C44H69N5O5S
Formula Weight
780.1
Purity
≥98%
Formulation(Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
- DMF: 20 mg/mL
- DMSO: 10 mg/mL
- Ethanol: 30 mg/mL
- PBS (pH 7.2): Slightly
SMILES
CC1=C(C2=CC=C(CNC([C@@H](N3C([C@@H](NC(CCCNC(CCCCCCC/C=C\CCCCCCCC)=O)=O)C(C)(C)C)=O)C[C@H](C3)O)=O)C=C2)SC=N1
InChi Code
InChI=1S/C44H69N5O5S/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-22-38(51)45-28-21-23-39(52)48-41(44(3,4)5)43(54)49-31-36(50)29-37(49)42(53)46-30-34-24-26-35(27-25-34)40-33(2)47-32-55-40/h13-14,24-27,32,36-37,41,50H,6-12,15-23,28-31H2,1-5H3,(H,45,51)(H,46,53)(H,48,52)/b14-13-/t36-,37+,41-/m1/s1
InChi Key
FOJJJSRIPHLZFB-HJBYGEKRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 3 years
| SKU | CAYM-38931-1 |
|---|---|
| Supplier Part Number | 38931-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| Energy Star | No |
| Green | No |
| Controlled | N |