Cayman UNC8153 (trifluoroacetate salt)

Sarpogrelate-d₃ is intended for use as an internal standard for the quantification of sarpogrelate (hydrochloride) (Item No. ) by GC- or LC-MS. Sarpogrelate is a selective antagonist of the serotonin (5-HT) receptor subtypes 5-HT_2A, 5-HT_2B, and 5-HT_2C (K_is = 3.02, 269, and 37.2 nM, respectively, for human recombinant receptors expressed in CHO-K1 cells). It is selective for 5-HT₂ (K_i = 70.8 nM) over 5-HT₁ (K_i = >26,000 nM), α₁-, α₂-, and β-adrenergic (K_is = 640-123,800 nM), and muscarinic receptors (K_i = >40,000 nM). In vitro, it inhibits aggregation of rat whole blood induced by collagen, 5-HT (Item No. ) with collagen, and 5-HT with ADP (Item No. ; IC₅₀s = 57.7, 0.56, and 22.7 μM, respectively). In vivo, it inhibits leukocyte-endothelial interactions in the femoral artery induced by a high-fat high-fructose diet (HFFD) in mice when administered at a dose of 5 mg/kg per day. Sarpogrelate (5 mg/kg per day) decreases ventricular hypertrophy and infarct size in a rat model of myocardial infarction.

WARNING This product is not for human or veterinary use.