Cayman PAMAM Dendrimer G3.0 Amine (water solution)

PAMAM dendrimer G3.0 amine (PAMAM G3.0) is a polyamidoamine (PAMAM) dendrimer with amine termini that has been used as a drug delivery system in vivo.^1,2 It is approximately 36 Å in diameter and has 32 surface groups.¹ It is cytotoxic to DU145 cells (IC₅₀ = ^~13.42 µM) and toxic to zebrafish embryos, inducing mortality 72 hours post-fertilization when used at a concentration of 0.2 µM.³ Liposomes coated with PAMAM G3.0 and encapsulating the isoquinoline alkaloid berberine (Item No. 10006427) and the anthraquinone chrysophanol (Item No. 19870) reduce hydrogen peroxide-induced production of reactive oxygen species (ROS) in ARPE-19 retinal epithelial cells and protect against retinal damage in a rat model of photooxidation-induced age-related macular degeneration (AMD).²

WARNING This product is not for human or veterinary use.