Cayman PAMAM Dendrimer G3.5 Carboxylate (sodium salt) (water solution)

PAMAM dendrimer G3.5 carboxylate (PAMAM G3.5) is a polyamidoamine (PAMAM) dendrimer with carboxylate termini that has been used as a drug delivery system in vitro and in vivo.^1,2 It is approximately 66.1 Å in diameter in water and has 48 surface groups.³ PAMAM G3.5 is active against E. coli (IC₅₀ = 22 mg/mL) and increases the mitochondrial membrane potential of isolated rat liver mitochondria when used at concentrations ranging from 10 to 50 µM.^4,5 Unlike amine-terminated PAMAM G4.0, PAMAM G3.5 (20 µM) is not toxic to zebrafish embryos.⁶ A fluorescently labeled form of PAMAM G3.5 enters Caco-2 cells via dynamin-, clathrin-, and caveolin-mediated endocytosis.⁷ Conjugates of PAMAM G3.5 with the active fragment of the DNA cross-linking agent oxaliplatin (Item No. 13106) are cytotoxic to A2780 ovarian, MCF-7 breast, and Caco-2 colon cancer cells and BJ fibroblasts (IC₅₀s = 0.08, 4.1, 0.39, and 3 µM, respectively).¹ PAMAM G3.5 in complex with the topoisomerase I inhibitor camptothecin (Item No. 11694) increases the oral bioavailability of camptothecin in mice.²

WARNING This product is not for human or veterinary use.