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Cayman NCT-02
List Price $145.00 Your Price $145.00
Cayman NCT-02 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-39568-5
MFG.PART: 39568-5
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
NCT-02 is a degrader of cyclin K.1 It reduces the levels of cyclin K in patient-derived colorectal cancer (CRC) cells in a concentration-dependent manner. NCT-02 inhibits cancer cell proliferation in CRC tissue samples isolated from the colon (IC50s = 0.9-20.6 µM), as well as from hepatic, lung, and rectal metastases (IC50s = 0.5-11.8, 1, and 1.4-38.4 µM, respectively). It decreases the levels of Ataxia-telangiectasia mutated kinase (ATM) and RAD51 in patient-derived CRC tissues when used at concentrations 0.7 and 0.5 µM, respectively. NCT-02 (3 µM) reduces the number of spheroids formed and induces poly(ADP-ribose) polymerase (PARP) cleavage in patient-derived CRC spheroid cultures.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
6,7-dihydro-
CAS Number
790245-61-3
Molecular Formula
C17H16N2O2S
Formula Weight
312.4
Purity
≥98%
Formulation(Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
- Acetonitrile: Soluble
- DMSO: Soluble
SMILES
O=C(NC1=NC=C(C)S1)CC2=COC3=C2C=C(CCC4)C4=C3
InChi Code
InChI=1S/C17H16N2O2S/c1-10-8-18-17(22-10)19-16(20)7-13-9-21-15-6-12-4-2-3-11(12)5-14(13)15/h5-6,8-9H,2-4,7H2,1H3,(H,18,19,20)
InChi Key
IELCYEUTXLYDOV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-39568-5 |
|---|---|
| Supplier Part Number | 39568-5 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 790245-61-3 |
| Energy Star | No |
| Green | No |
| Controlled | N |