Cayman YCH1899

YCH1899 is an inhibitor of poly(ADP-ribose) polymerase 1 (PARP1) and PARP2 (IC₅₀s = <0.001 nM for both).¹ It is selective for PARP1 and PARP2 over PARP3, -4, -5A, -5B, -6, -7, -10, and -12 (IC₅₀s = 1-14.1 nM). YCH1899 inhibits the proliferation of Capan-1 cells (IC₅₀ = 0.1 nM), as well as Capan-1 cells resistant to the PARP inhibitors talazoparib (BMN 673; Item No. 19782) or olaparib (Item No. 10621; IC₅₀s = 1.13 and 0.89 nM, respectively). It inhibits the proliferation of BRCA1 mutant HCC1937 breast cancer cells (IC₅₀ = 4.54 nM). In vivo, YCH1899 (12.5 and 25 mg/kg) reduces tumor growth in an olaparib-resistant MDA-MB-436 breast cancer mouse xenograft model.

WARNING This product is not for human or veterinary use.