Cayman (−)-α-Thujone

(–)-α-Thujone is a monoterpene ketone and a major component of absinthe and has diverse biological activities.^1,2,3,4 It inhibits currents induced by acetylcholine (ACh) in Xenopus oocytes expressing human α7 nicotinic acetylcholine receptors (nAChRs; IC₅₀ = 27 µM).¹ (–)-α-Thujone (100 and 300 µM) reduces GABA-induced current amplitude in HEK293 cells expressing α₁β₂δ subunit-containing GABA receptors.² It reduces levels of the Norovirus surrogates feline calcivirus-F9 (FCV-F9) and murine norovirus 1 (MNV-1) in a plaque formation assay when used at a concentration of 25 mm.³ In vivo, (–)-α-thujone (1.25 mg/kg, i.p.) impairs nicotine-induced enhancement of long-term potentiation in the dentate gyrus, a marker of learning and memory, in rats.¹ It also inhibits lung metastasis and increases survival in a B16/F10 murine melanoma model when administered at a dose of 1 mg/kg.⁴

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