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Cayman GYKI 53655
List Price
$154.00
Your Price
$154.00
Cayman GYKI 53655 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-39842-5
MFG.PART:
39842-5
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
GYKI 53655 is an allosteric AMPA receptor antagonist.1 It inhibits AMPA- and kainite-induced inward currents in whole-cell patch-clamp assays using primary rat hippocampal neurons (IC50s = 1.1 and 1.5 µM, respectively). GYKI 53655 decreases tonic and clonic audiogenic seizure severity in mice (ED50s = 1.3 and 2 mg/kg, respectively) and reduces mortality in a mouse model of global cerebral ischemia induced by magnesium dichloride (ED50 = 8.2 mg/kg).2 It inhibits seizures induced by maximal electroshock (MES) in mice (ED50 = 4.6 mg/kg) but induces motor impairment at a half-maximal toxic dose (TD50) value of 8.7 mg/kg.1
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
5-(4-amino
CAS Number
143692-48-2
Synonyms
- LY300168
Molecular Formula
C19H20N4O3 • HCl
Formula Weight
388.9
Purity
≥95%
Formulation(Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
- Acetonitrile: Soluble
- DMSO: Soluble
SMILES
O=C(N1N=C(C2=C(CC1C)C=C3OCOC3=C2)C4=CC=C(N)C=C4)NC.Cl
InChi Code
InChI=1S/C19H20N4O3.ClH/c1-11-7-13-8-16-17(26-10-25-16)9-15(13)18(22-23(11)19(24)21-2)12-3-5-14(20)6-4-12;/h3-6,8-9,11H,7,10,20H2,1-2H3,(H,21,24);1H
InChi Key
ASLCSBBDVWPSQT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-39842-5 |
|---|---|
| Supplier Part Number | 39842-5 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | Y |
| CAS Number | 143692-48-2 |
| Energy Star | No |
| Green | No |
| Controlled | N |