Cayman PB-22 (exempt preparation)

Indacaterol-d₃ is intended for use as an internal standard for the quantification of indacaterol (Item No. ) by GC- or LC-MS. Indacaterol is a long-acting and selective β₂-adrenergic receptor (β₂-AR) agonist (EC₅₀ = 8.71 nM for increasing intracellular cAMP levels in vitro). It is selective for β₂-ARs over β₁- and β₃-ARs (K_is = 43.6, 616.6, and 3,311.3 nM, respectively). Indacaterol inhibits bronchoconstriction induced by serotonin (5-HT; Item No. ) in conscious guinea pigs with a maximal effect of 85% when administered intratracheally at a dose of 6.7 µg/kg. It also inhibits bronchoconstriction induced by methacholine (Item No. ) in rhesus monkeys with a maximal effect of 75% when administered via nebulization at a dose of 12.5 mg/kg. Formulations containing indacaterol have been used alone, and in combination with glycopyrrolate, in the treatment of chronic obstructive pulmonary disease.

WARNING This product is not for human or veterinary use.