Cayman IFN-γ (mouse) TR-FRET Biomarker Assay Kit

UTP is a nucleotide and dual agonist of purinergic P2Y₂ and P2Y₄ receptors (EC₅₀s = 55 and 80 nM, respectively, for stimulation of phospholipase C in 1321N1 cells expressing human receptors).^, It is selective for P2Y₂ and P2Y₄ receptors over P2Y₆ receptors (EC₅₀ = >10,000 nM). UTP stimulates proliferation of PANC-1 cells (EC₅₀ = 13.1 μM), an effect that can be prevented by siRNA against the P2Y₂ receptor. It induces vasoconstriction in perfused isolated canine epicardial coronary artery in a concentration-dependent manner. UTP is formed from uridine monophosphate (UMP) by two sequential phosphorylations and can be converted to cytidine 5-triphosphate (CTP; Item No. ). It also reacts with glucose-1-phosphate (Item No. ) to form UDP-glucose (Item No. ), a precursor in the biosynthesis of glycogen.

WARNING This product is not for human or veterinary use.