Cayman 32-cGAMP ELISA Kit

Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that controls genes involved in glycolysis, angiogenesis, migration, and invasion. Echinomycin is a cell-permeable inhibitor of HIF-1-mediated gene transcription.^, It acts by intercalating into DNA in a sequence-specific manner, blocking the binding of either HIF-1α or HIF-1β to the hypoxia-responsive element.^,, Echinomycin reversibly inhibits hypoxia-induced HIF-1 transcription activity in U215 cells with an EC₅₀ value of 1.2 nM. It inhibits hypoxia-induced expression of vascular endothelial growth factor, blocking angiogenesis and altering excitatory synaptic transmission in hippocampal neurons.^, Echinomycin also impairs expression of survivin, enhancing the sensitivity of multiple myeloma cells to melphalan.

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