Cayman Glutamate Colorimetric/Fluorometric Assay Kit

(–)-L-threo-PDMP is a ceramide analog and one of the four possible stereoisomers of PDMP (Item No. ). L-threo-PDMP is an enhancer of ganglioside biosynthesis.^, It increases glucosylceramide synthase activity by 4 and 8% when used at concentrations of 5 and 2.5 µM, respectively, in an enzyme assay. L-threo-PDMP increases the activity of ganglioside GM₃, GD₃, and GQ_1b synthases and increases the levels of glucosylceramide, lactosylceramide, and ganglioside GM₃ in B16 melanoma cells.^, It inhibits the growth of MCF-7, MDA-MB-468, SK-BR-3 cells with IC₅₀ values of 4, 7, and 6 µM, respectively. L-threo-PDMP increases neurite outgrowth and synapse formation in vitro and improves retention of a long-term memory learned prior to forebrain ischemia in rats when administered following ischemia at a dose of 40 mg/kg per day. The L-threo-PDMP isomer is the glucosylceramide synthetase stimulatory component of DL-threo-PDMP (Item No. ), while D-threo-PDMP (Item No. ) is the inhibitory component. [Matreya, LLC. Catalog No. 1749]

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